Th2-mediated dermatoses, encompassing conditions such as atopic dermatitis, chronic spontaneous urticaria, prurigo nodularis, bullous pemphigoid, cutaneous mastocytosis, and certain parasitic dermatoses, are characterized by a dominant type 2 immune response orchestrated by cytokines including interleukin-4 (IL-4), IL-5, IL-13, and IL-31 [83,84]. Here, IL4 is linked to chronic idiopathic urticaria.