RAPGEF5 and Increased total leukocyte count: Similar results occurred when evaluating cluster assignment in the context of patient characteristics (age, NYHA class), laboratory parameters (CRP, Leukocytosis, GFR, hsTNT, NTpro-BNP), and echocardiographic parameters (MAPSE, EDD, PW, IVS) (see Figure 4G)—the parameter clustering for the death/transplantation endpoint were still retained (Figure 4G).