ST3GAL3 and cancer: On the other hand, in order to investigate the relevance of different α-2,3-sialyltransferases (ST3GALs) in GBM, Putthisen et al. used in silico analyses to show an increased mRNA expression levels for ST3GAL2, ST3GAL4, ST3GAL6, and a slightly decrease for ST3GAL1, ST3GAL3, and ST3GAL5 in GBM tissues, compared to non-cancer tissues [2].