Firstly, querying the R2 genomic platform to investigate the mRNA expression level of the various sialyltransferases in GBM, we have elicited our attention on β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1), β-galactoside α-2,3-sialyltransferase 2 (ST3GAL2), and the PolySia-producing enzyme ST8SIA4. This evidence concerns the gene ST6GAL1 and glioblastoma.