TNF and malignant colon neoplasm: For example, gigantol from D. Draconis was shown to attenuate the stemness of lung cancer cells [49]; denbinobin from D. nobile can block the growth or motility of lung, ovarian, prostate, and colon cancer cells [31,50,51,52,53]; glucomannan from D. officinale regulates the production of IL-1β and TNF-α in THP-1 cells [54]; and phenanthrenes from D. nobile suppress LPS-induced NO generation in RAW 264.7 macrophages [55].