One member of the vanilloid TRP family, TRPV1, mediates the sensing of the carotid body to Th2 cytokines and lysophosphatidic acid [12,13], and a member of the melastatin TRP family, TRPM7, is involved in the regulation of obesity-induced hypertension mediated by leptin [3,8]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.