PTK2 and glioblastoma: ADAM10 has also been shown to function in tumour crosstalk with the GBM microenvironment (TME) [18], shedding the synaptic adhesion molecule neuroligin-3 (NLGN3) from neurons and oligodendrocyte precursor cells, which promotes GBM proliferation through the focal adhesion kinase (FAK) and PI3 kinase–mTOR pathways [19].