Amongst these, ECM and adhesion proteins were again prominent, including ACAN, OGN, HAPLN1, OLFML3, and the integrin-binding Tenascin N. Several ECM-associated proteins were only identified in the mouse protein search, such as multiple fibrinogens, Cartilage Oligomeric Matrix Protein (Comp), and Cathepsin K, indicating that KO of ADAM10 from tumour cells modulates the TME cell types contributing to matrix remodelling, particularly related to stromal fibroblasts. Here, ACAN is linked to neoplasm.