Previous studies have shown putative roles of ADAM10 in a variety of functions, including promoting cell stemness, migration and invasion in vitro [14], modulating immunogenicity [34,35,40], and mediating tumour-microenvironment cross-talk via shedding of the synaptic adhesion molecule neuroligin-3 (NLGN3) from neuronal cells [19]. Here, ADAM10 is linked to neoplasm.