Although the association of resistin with CAD and its severity was shown in different cohorts (NSTEMI, STEMI, stable angina) [9,10,11], the impact of this cytokine on the expanse of coronary lesions in subjects with ACS displaying other lesions apart from the culprit evaluated with extensive functional and anatomical tests such as FFR and OCT was not previously evaluated. This evidence concerns the gene RETN and angina pectoris.