Patient P08 exhibited an atypical pre-therapy expression profile of immune-related genes, indicative of underlying immune dysfunction, and experienced a pronounced decline in the CD4/CD8 ratio (from 1.12 at baseline to 0.26 post-ART) driven by a disproportionate expansion of CD8+ T cells (from 576 to 1990 cells/μL). The gene discussed is CD4; the disease is immune system disorder.