Among other molecules that have been identified as cargo in EVs involved with cancer are integrin B1 that mediates EV uptake and RNA delivery [35], fibronectin and the induction of its assembly [35,36], osteopontin involved in the signaling process [37], cytokines that modulate metabolism and tumor microenvironment [33], and Hsp70, which is commonly found in small EVs [34]. This evidence concerns the gene FN1 and neoplasm.