ERBB2 and breast cancer: In our bioinformatics analysis, higher GATA4 methylation was associated with longer PFI, which contrasts with findings from other studies reporting that GATA4 suppresses cell proliferation, invasion, and migration, while promoting apoptosis and senescence in breast cancer cells which lacks hormone receptors and HER2, GATA4 may interact with different transcriptional networks, possibly resulting in context-dependent effects, including pro-tumor functions when overexpressed [29,30].