Increased mRNA expression of TRPV1 was observed in peripheral blood mononuclear cells of patients with psoriasis [35], while knockout of the TRPV1 gene in the IMQ-treated mice resulted in a reduction in inflammatory cell infiltration and the expression levels of inflammatory cytokines (IL-1β, IL-6, IL-23-A, and S100A8) in skin lesions [23]. The gene discussed is S100A8; the disease is psoriasis.