Similar to ACD, psoriasis is caused primarily by TNF-α, IL-1β, and IL-6 produced by keratinocytes, which stimulate plasmacytoid dendritic cells to produce interferon-α (IFN-α) followed by its stimulation of IL-12 and IL-23 release by dendritic cells nearby lymph nodes. This evidence concerns the gene IL1B and granular corneal dystrophy type II.