In the skin, TRPV1 is present on the membranes of keratinocytes, mast cells, Langerhans cells, sebocytes, sweat gland cells, and hair follicles, and it plays an important role in skin inflammation, pain, and itching, contributing significantly to the pathogenesis of dermatitis and psoriasis [21,22]. The gene discussed is TRPV1; the disease is psoriasis.