MAPT and Alzheimer disease: Furthermore, polyphenols from olive oil and grapes [50,51], olive fruit extract rich in hydroxytyrosol [52], olive leaf extract enriched in oleuropein [53], strawberry extract [54], Manuka honey and beeswax [55,56], and Curcumin [57] have been able to modulate tau hyperphosphorylation and Aβ aggregation in in vivo models of AD.