In this study, we generated FABP4 knockout (FABP4−/−) TRAMP mice by crossing TRAMP mice with FABP4−/− mice, and found that FABP4 knockout diminished HF-induced tumor development and progression in TRAMP mice while maintaining their body weight and modulating systemic cytokine secretions and intratumoral pan-amino acid synthesis. This evidence concerns the gene FABP4 and hydrops fetalis.