NPPB and heart failure: Additionally, in the positive group, significantly higher NT-proBNP levels (p = 0.003) along with a higher prevalence of heart failure (p = 0.006) support the hypothesis of increased hemodynamic overload of the right heart due to an elevated pulmonary pressure, further confirmed by a significantly higher probability of resting pulmonary hypertension in this group (p < 0.001).