To our knowledge, this study represents the first analysis of the identified genes (ABCG2, ABHD4, MOBKL1A, AK3, SDE2, PRAMEF4, CREM, CDH4, BRAT1, SDK1, NR3C2, ACTG1, COG5, CAT, HDAC4, FTO, DOK7, OCLN, and ATXN1) in the context of sleep and obesity-related DNA methylation changes in children. This evidence concerns the gene CAT and obesity due to melanocortin 4 receptor deficiency.