To our knowledge, this study represents the first analysis of the identified genes (ABCG2, ABHD4, MOBKL1A, AK3, SDE2, PRAMEF4, CREM, CDH4, BRAT1, SDK1, NR3C2, ACTG1, COG5, CAT, HDAC4, FTO, DOK7, OCLN, and ATXN1) in the context of sleep and obesity-related DNA methylation changes in children. The gene discussed is CDH4; the disease is obesity due to melanocortin 4 receptor deficiency.