Cross-comparison analyses revealed ten additional genes, CDH4, NR3C2, ACTG1, COG5, CAT, HDAC4, FTO, DOK7, OCLN, and ATXN1, that were differentially methylated by sleep timing and have also been implicated in obesity-related pathways (Table A2 in Appendix A provides full abbreviations and functions), suggesting an epigenetic interface connecting circadian regulation and metabolic health. The gene discussed is HDAC4; the disease is obesity due to melanocortin 4 receptor deficiency.