BRCA1 and breast carcinoma: A recent study further showed that RAPTA-T causes much more cellular BRCA1 damage in triple-negative BRCA1-defective HCC1937 breast cancer cells than in sporadic BRCA1 wide-type MCF-7 breast cancer cells, leading to a reduction in both BRCA1 mRNA expression and the BRCA1 protein in both cell lines [38].