EGFR and neoplasm: The accumulation of both variants was much higher in A-431 xenografts than in Ramos xenografts (p < 0.05, unpaired t-test), which demonstrated that the tumor uptake of both [99mTc]Tc-(HE)3-E01 and [123I]I-(HE)3-E01-PIB was EGFR-specific (Figure 6B).