Interestingly, MSX1 deficiency disrupts the growth of the medial nasal process in mice, and this is exacerbated by hypoxia during pregnancy [50], which might mean that a similar process could also be happening during human cleft lip morphopathogenesis in developing craniofacial connective tissue and blood vessels, although additional research is needed to confirm this suggestion. The gene discussed is MSX1; the disease is cleft lip.