In the context of this ROS-based mechanism, we asked whether the new PrC-210 aminothiol ROS scavenger (Figure 1), the best direct-acting ROS scavenger in biology when compared to the 13 other ROS scavenger/antioxidants most cited in PubMed [22,26], could effectively suppress the severity of EAE-induced MS in mice. This evidence concerns the gene PPRC1 and myeloid sarcoma.