This was further evidenced in stromal interaction molecule 1/2 (STIM1/2) Foxp3+ mice, where targeted deletion of calcium-sensing proteins STIM1/2 in Foxp3+ Tregs resulted in a fulminant SS-like phenotype characterized by lacrimal gland inflammation, lymphocytic infiltration, and IFN-γ–dominated transcriptional signatures [102]. The gene discussed is STIM1; the disease is synovial sarcoma.