The local production of CCL20 would be consistent with the lack of correlation between plasma and urinary CCL20 and may also be consistent with the trend towards higher plasma levels with more severe (larger kidneys) ADPKD, as well as higher urinary levels in DKD patients with A2–A3 albuminuria or in the G4 category. This evidence concerns the gene CCL20 and autosomal dominant polycystic kidney disease.