A recent CRC study showed that F. nucleatum of gut origin can drive CXCR1+ PD-L1+ phagocytes to migrate to tumors, further recruit PMN-macrophages via the CXCL2/8-CXCR2 and CCL5/CCR5 axes, promote tumor progression, and impair immunotherapy [155]. This evidence concerns the gene CD274 and neoplasm.