FGF2 and melanoma: In hindlimb ischemia models, bicistronic vector delivery of fibroblast growth factor 2 (FGF2) and cellular communication network factor 1 (Cyr61) with FGF1 IRES stimulated synergistic angiogenesis with significantly lower doses of the angiogenic factors, and avoided systemic undesirable effects on accelerating B16 melanoma growth caused by robust expression from a monocistronic vector [77].