By fusing a gasdermin D mutant to a mitochondrial-targeting peptide, they harnessed mitochondrial inner membrane cardiolipin toxicity to trigger mitophagy-mediated tumor cell death, which markedly suppressed tumor growth in xenograft models of EIF4G2+/PTBP1+ adenocarcinomas [127]. The gene discussed is EIF4G2; the disease is neoplasm.