Similarly, the circRNA vaccine incorporating Enterovirus-A (EV-A) IRES to express multiple tumor neoantigens, elicited high levels of neoantigen-specific CD8+ T cell responses, dendritic cell activation, and durable tumor regression in murine models of melanoma and hepatocellular carcinoma, while the control groups receiving traditional linear mRNA vaccines or non-optimized circRNAs showed significantly weaker immunity and inferior tumor control [99]. Here, CD8A is linked to melanoma.