It is, however, important to proceed with research on the interruption of TNFRs, as anti-TNF drugs cause severe side effects, e.g., an increase in infections, the risk of developing malignant tumors, and autoimmune conditions such as psoriasis, vasculitis, demyelinating disorders (disruption of nerve signals), and anti-TNF-induced lupus (ATIL) [102]. The gene discussed is TNF; the disease is infection.