CRH and irritable bowel syndrome: Irritable bowel syndrome (IBS), defined as one of the indicators of MetS, is linked to elevated triglycerides, LPS, Corticotropin-Releasing Factor (CRF), total cholesterol, and LDL cholesterol levels, abdominal obesity, stress, anxiety, depression, long-term antibiotic use, age, gender, diets, and increased waist circumference.