Drastic changes in the levels of triglyceride, LDL, uric acid, C-reactive protein, catecholamine, cortisol, TMA, ImP, glucagon-like peptide 1 (GLP-1), peptide tyrosine-tyrosine (YY), IFN-γ, TLR2, and CD36 may serve as an early warning of MetS. This evidence concerns the gene GCG and metabolic syndrome.