STAT3 and cancer: In particular, in the field of cancer therapy, plant-derived active ingredients can act through multiple biological signaling pathways, such as STAT-3, PI3K/Akt, and EGFR, which results in the inhibition of cell proliferation, induction of apoptosis, and inhibition of the epithelial–mesenchymal transition (EMT) involved in cancer cell metastasis [10].