CCL2 and myeloid sarcoma: This is closely related to the increased microvascular density in the kidney of rats exposed to MS [23], since cytokines and chemokines involved in inflammation contribute to microvascular changes by acting synergistically [37]; in particular, CXCL6 and CCL2 enhance neutrophil chemotaxis, which indirectly favors angiogenesis through increased leukocyte infiltration and the subsequent release of proangiogenic factors [38].