DNMT3A and infection: Surprisingly, DNMT3A expression increases in CC patients with the methylated immunostimulatory motif of E6 and E7 regions and low hypomethylation within Alu repeat sequences, and its expression decreases in CC patients with the same unmethylated motif and high DNA hypomethylation at the Alu repeat sequences compared with HPV-negative controls, suggesting that DNMT3A could favor a differential molecular signature between patients with CC and infection by HR-HPV16 [120].