CASP3 and cancer: The investigation into the anti-cancer effects in PTC, revealed that sanguinarine treatment significantly inhibited cell proliferation of PTC cells BCPAP and TPC-1 in a dose and time-dependent manner through apoptosis and autophagy signaling cascades at 4 μM, including p-STAT3, caspase-3, caspase-8, PARP cleavage, and the generation of reactive oxygen species [112].