Interestingly, among the genes that were down-regulated in D614G, Alpha and Gamma VOCs, we found important key players of innate immunity, like TMEM173, also known as STING1, which plays a key role in the production of type I interferons (IFNs) and pro-inflammatory cytokines, as well as in autophagy and cell death mechanisms in response to pathogens infections [18]. Here, STING1 is linked to infection.