PMAIP1 and autoimmune disease: Taken together, the combination of significantly increased B3GAT1 (CD57), PMAIP1, CD52 and CD69 in the aged NKPs at the pre-B developmental stage is consistent with immunosenescence with loss of proliferative capacity and compromised immune response, identified by high CD57 and PMAIP1, and with inflammaging, identified by high CD57 expression and risk of autoimmune diseases, indicated by elevated CD52 and CD69 expressions.