Glycine can reduce the expression of GPX4 and FTH1 by increasing the methylation of GPX4 promoter mediated by the concentration of S-adenosine methionine (SAM) and reducing the expression of FTH1 in RA and FLS, thereby enhancing ferroptosis and achieving the effect of RA treatment [85]. This evidence concerns the gene FTH1 and rheumatoid arthritis.