SLC7A11 and hepatocellular carcinoma: Wang et al. further demonstrated that IFN-γ sensitizes adrenocortical carcinoma cells to erastin-induced ferroptosis by downregulating SLC7A11 via the JAK/STAT pathway [37] Furthermore, in hepatocellular carcinoma, IFN-γ was found to activate the JAK/STAT pathway, subsequently downregulating the mRNA and protein levels of SLC3A2 and SLC7A11, key components of system Xc− [38] Beyond this, STAT family members are directly involved in regulating the expression of ferroptosis-related molecules.