Intracellular inflammatory pathways, such as NF-kB, Janus kinases (JAK)/Signal Transducers and Activators of Transcription (STAT), and the activation of the NLRP3 inflammasome, orchestrate metaflammation, which contributes to the pathogenesis of insulin resistance, T2DM, and cardiovascular disease [111]. This evidence concerns the gene NFKB1 and Insulin resistance.