Our recent work showed that co-treatments of glioblastoma cells with the unsaturated fatty acid docosahexaenoic acid (DHA) and dPGS, as well as aminated dPG (dPGA), showed additive positive effects in killing glioma cells due to disruption of the HMGB1/RAGE axis [54]. Here, HMGB1 is linked to glioblastoma.