Additionally, PPS may target signaling pathways involved in psoriasis, such as NF-κB, janus kinase/signal transducer and activator of transcription (JAK-STAT) and non-receptor tyrosine-protein Kinase (TYK2) pathways, MAPK pathway, and phosphoinositide 3-kinase/Akt (PI3K-AKT) pathway [9,57]. The gene discussed is TYK2; the disease is psoriasis.