Consistent with previous studies, we observed in TCGA datasets that NSCLC tumors exhibit upregulation of hypoxia-associated genes including HIF1α, GLUT1, LDHA, PDK1, MCT4, and CAIX, which collectively promote glycolytic metabolism, lactate accumulation, and extracellular acidification [34]. Here, PDK1 is linked to non-small cell lung carcinoma.