Transcriptional abnormalities in hippocampal Tns3 (regulating synaptic adhesion) and Nfkbia (inhibiting the NF-κB inflammatory pathway) may provide targets for developing ‘adolescent cannabinoid injury repair drugs.’ Current clinical diagnosis of synthetic cannabinoid poisoning relies primarily on history and symptoms (e.g., agitation, hallucinations, memory impairment), lacking objective biomarkers. Here, NFKB1 is linked to memory impairment.