ABCC11 and cancer: As the ABCC11 efflux pump secretes molecules from the cytoplasm to the intercellular space, the wild type of ABCC11 is strongly related to resistance to cancer drugs such as 5-fluorouracil (5-FU), 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP), cytosine arabinoside (Ara-C), pemetrexed (MTA), methotrexate (MTX), and 9′-(2′-phosphonyl-methoxyethyl)adenine (PMEA) [108].