CD4 and mycosis fungoides: Of the 19,909 CD4 T cells identified across all groups and the 4168 that were malignant, CD5 expression was significantly increased in malignant CD4 T cells from all MF patients (log2 fold change of 1.85, adjusted p-value < 0.0001), indicating elevated CD5 expression in malignant MF CD4 T-cells relative to healthy skin (Figure 2E).