In a study conducted by Yoshimura et al. [82], employing a rat inflammatory arthropathy model, gene delivery of 7ND significantly suppressed the histological fibrosis in the IFP, decreased macrophage infiltration in synovial tissues, and led to a notable reduction in local CCL2 levels, apparently produced by infiltrating macrophages, ultimately inhibiting CCL2-mediated macrophage migration, and lowering the production of inflammatory cells and additional chemokines in the IFP. This evidence concerns the gene CCL2 and arthropathy.