Attenuates myocardial inflammation, mitigates atherosclerosis progression, prevents vascular dysfunction and inflammation, modulates excessive inflammatory response in periodontal disease, and decreases TREM-1 dimerization on monocytes and neutrophils. It also promotes hepatocyte regeneration in TAA-induced ALF and reduces aortic inflammation in AAA. This evidence concerns the gene TREM1 and periodontal disorder.