TREM1 and intracerebral hemorrhage: TREM-1 plays a crucial role in intracerebral hemorrhage (ICH)-induced brain damage, leading to significant behavioral impairment and mortality. In mice, Trem-1 knockdown using CRISPR improved neurobehavioral outcomes compared to ICH+ control CRISPR mice. Trem-1 knockdown mice exhibited reduced TREM-1 expression in microglia after ICH, along with decreased IL-1β levels and an increase in anti-inflammatory factors such as M2 (Arg-I).