Trem-1 KO mice were found to be more vulnerable to oral infection with Klebsiella pneumoniae due to translocation in the small intestine. Mice infected with Klebsiella pneumoniae liver abscess (KPLA) exhibited higher mortality rates. This highlights the critical role of TREM-1 signaling in defending the host against bacterial infections and supporting effective mucosal immunity in the small intestine. Overall, Trem-1-KO mice displayed increased bacterial dissemination, liver and systemic inflammation, and higher mortality. This evidence concerns the gene TREM1 and Klebsiella pneumonia.