The pathophysiology of the systemic COVID-19 is characterized by a diverse array of immunomodulatory and pro-inflammatory cytokines, including interleukins IL-1β, IL-2, IL-6, IL-7, IL-10, IL-18, interferon-gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), granulocyte–macrophage colony-stimulating factor (GM-CSF), interferon gamma-induced protein 10 (IP-10), macrophage inflammatory protein 1 alpha (MIP-1α), chemokine (C-C motif) ligand 2 (CCL2/MCP-1), along with D-Dimer and C-reactive protein (CRP). This evidence concerns the gene IFNG and COVID-19.