HSD17B1 and neoplasm: Figure 8F illustrates the distribution of intergroup DEGs across cell types, with HSD17B1 showing predominant expression in epithelial cells (Figure 8G). Subcellular localization analysis revealed that HSD17B1 was primarily expressed in the cytosol (Figure 8H and Figure S4D). Integration of inferCNV analysis showed that epithelial cells (clusters 7, 13, and 15) exhibited pronounced copy number alterations (CNAs), suggesting potential epithelial–mesenchymal transition (EMT) within the tumor microenvironment (Figure 8I).