APAF1 and acute myeloid leukemia: In an acute myeloid leukaemia model, QCT exhibited epigenetic effects, reducing the levels of DNA methyltransferases (DNMTs), histone deacetylase 1 (HDAC1), and histone deacetylase 2 (HDAC2), while increasing the expression of pro-apoptotic genes, including death-associated protein kinase 1 (DAPK1), apoptotic peptidase activating factor 1 (APAF1), Bcl-2-like protein 11 (BCL2L11), and Bax.