In another study involving patients with the same type of cancer, supplementation with a mixture of phenolic compounds (curcumin, red clover, flaxseed, resveratrol) increased metabolite concentrations in tumour tissues and activated the p53/p21 pathway, resulting in cell cycle arrest (p < 0.05) and apoptosis of MCF-7 cells (p < 0.05) [30]. Here, TP53 is linked to neoplasm.