RB1 and neoplasm: RHSD effectively reduced the expression of human papillomavirus (HPV) early protein 6 (E6) (p < 0.01) and early protein 7 (E7) (p < 0.01) oncogenes and increased levels of p53 (p < 0.01) and retinoblastoma protein 1 (Rb1) (p < 0.001) tumour suppressors, leading to apoptosis via these pathways [48].