A low clonal burden of JAK2 V617F is typically associated with phenotypes such as clonal hematopoiesis of indeterminate potential or essential thrombocythemia (ET), while a high clonal burden is more often linked to polycythemia vera (PV) or post-PV myelofibrosis (MF) [70]. This evidence concerns the gene JAK2 and essential thrombocythemia.