Specific single-nucleotide polymorphisms (SNPs) in NOS3, such as c.-786T>C (rs2070744) and c.894G>T (p.Glu298Asp, rs1799983), affect endothelial NOS (eNOS) activity, which may exacerbate vascular dysfunction and worsen sepsis outcomes by impairing vascular tone and increasing the susceptibility to shock [8,9,12]. This evidence concerns the gene NOS3 and Sepsis.