LEP and obesity due to melanocortin 4 receptor deficiency: On the molecular level, thrombosis in obesity can arise through several pathways, including the effects of adipose tissue-derived cytokines like leptin and adiponectin, enhanced coagulation processes coupled with impaired fibrinolysis, persistent inflammation, oxidative stress leading to endothelial damage, and metabolic disturbances involving lipids and glucose commonly seen in metabolic syndrome (MetS) [4].