Microvillus and ciliary plasma membrane are components downregulated here in the no hydrocephalus AQP4−/−-NH mouse compared to the WT animal (Figure 3C and Supplementary Table S3), sustaining again that affectation of the aqueduct ependyma membrane and its cilia might result in stenosis of the aqueduct of Sylvius and development of obstructive hydrocephalus in some cases. This evidence concerns the gene AQP4 and obstructive hydrocephalus.