For instance, the E3 ubiquitin ligase FBXL2, a member of the conserved F-box protein family, targets both EGFR and tyrosine kinase inhibitor (TKI)-resistant EGFR mutants for proteasome-mediated degradation in EGFR-driven non-small cell lung cancer (NSCLC). The gene discussed is FBXL2; the disease is non-small cell lung carcinoma.