Recent strategies involve delivering key transcription factors such as Pancreatic and duodenal homobox 1 (PDX1), musculoaponeurotic fibrosarcoma bZIP transcription factor A (MAFA), and Paired box 6 (PAX6) to enhance β-cell function and survival, offering a personalized approach to diabetes treatment PDX1 [9]. The gene discussed is PDX1; the disease is diabetes mellitus.