As expected, several previously reported genes with abnormal methylation in leukemias such as CPEB1, BLK, FLT3, ZCCHC7, EBF1, HDACs, IKZF1, RB1, CDK6, DOCK5, DPP10, MUC4, JAKs, KIT, KRAS, LINC01013, MAD1L1, NOTCH1, and STATs, among others, were also detected (Supplementary Table S1). The gene discussed is NOTCH1; the disease is leukemia.